Cyrex Labs Wheat/Gluten Reactivity & Autoimmunity (Array 3)
Cyrex Labs is the World’s leading immunological/intolerance laboratory in the world. The Array 3 was specifically designed to measure multiple antibodies that appear when wheat or gluten causes an immune reaction in the body.
Gluten sensitivity is a hot topic and rightfully so. There are lots of misconceptions about it and the majority of our staple food contain it. It’s quite hard to avoid and therefore produces lots of resistance between people (not to mention food industry). New studies undoubtedly show that 36% of the population has an intolerance to wheat containing proteins. And 36% is a lot. This means that if you are in a room with 2 other people, one of you has wheat sensitivity.
An intolerance or reactivity to wheat means, that when you eat it, your body will mount an immune response to it and try to destroy what it perceives as a pathogen. Doing this it will also destroy your own cells thus damaging your tissues and organs. You then perceive this as autoimmune disease, the most common being Celiac disease. It is less know that what sensitivity reacts also with multiple other organs such as liver, bone, joints, skin, thyroid and many other.
Betweengenetic susceptibility, broken intestinal barriers,and environmental triggers, wheat, due to its structural similarity to a variety of human tissues, plays a major role in autoimmunities.
It is therefore important to know weather you are gluten sensitive, to be able to avoid it and to avoid chronic illness in the future.
The best test for wheat/gluten intolerance
Why is Cyrex Labs Array 3 the best test for gluten intolerance?
Wheat is made up of multiple proteins and peptides. Therefore, to properly assess wheat/gluten reactivity, a full array of proteins and peptides must be included. Cyrex is a pioneer in the measurements of multiple wheat protein immune reactivity.
Current testing for Gluten-Reactivity and Celiac Disease includes only serum IgG and IgA against gliadin and tissue transglutaminase-2 (tTG2). Why, if there are several proteins in wheat, do we assess reactivity to only one? Up to 86 % of patients recognize a different array of peptides. For example, one patient reacts to omega-gliadin, but not to alpha-gliadin. The second patient reacts to all gliadin peptides, and the third patient reacts only to the wheat germ agglutinin.
Cyrex labs does it differently. For a comprehensive approach to prevent false negatives resulting, patent-pending technologies have been developed to measure IgA and IgG against wheat as the combination of gluten and non-gluten proteins/peptides as well as the components: non-gluten proteins including the lectin, wheat germ agglutinin (WGA), and antigens farinin, serpin, globulin and alpha-amylase; gliadin toxic peptides; gluten family proteins/peptides (alpha-gliadins, -17-mer and native + deamidated -33-mer, gamma-gliadin-15-mer, omega-gliadin-17-mer, glutenin-21-mer); opioid peptides (prodynorphin + gluteomorphin);gliadin-transglutaminase complex, and enzymes (tissue transglutaminases -2, -3, -6 and non-tissue transglutaminase).
This then makes for the first whole wheat intolerance test available.
Cyrex’s Four Pillars of Excellence:
Antigen Purification System™ – ensures assessment to the un-adulterated antigen, resulting in greater specificity.
Optimized Antigen Concentration™ – optimum protein ratios to detect immune reactivity (i.e. Beef is much higher in protein than Oranges).
Antigen Specific Validation™ – single antigen validation, rather than one arbitrarily chosen reference curve entire group of antigens.
Parallel Testing Technology™ – each specimen is validated in side-by-side duplicate.
Together, the Four Pillars of Excellence ensure accurate results.
Completing the test
Completing the test is easy. Everything you need is included in the collection kit and you will also get detailed instructions as a downloadable PDF file once your order is complete.
This is a blood test so you will have to schedule a blood draw at your local laboratory. Any local laboratory should be able to complete the blood draw and process the samples. Please call your local lab and ask them if they can take your blood and process it in a centrifuge and separate the serum in the provided standard vials.
It’s really a simple and standard procedure but please make sure you can do it before you order this test.
About Cyrex laboratories
Cyrex Labs is an advanced clinical laboratory focusing on mucosal, cellular, and humoral immunology and specializing in antibody arrays for complex thyroid, gluten, and other food-associated autoimmunities and related neurodysregulation. Cyrex’s Scientific Advisory Board, comprised of experts from a variety of medical and research disciplines, brings together the latest findings from medical research and the assessment needs of today’s healthcare professionals. Out of this collaboration, Cyrex develops the next generation of clinical lab testing that is required to care for present-day complex maladies.