Cyrex Labs Leaky Gut test/Intestinal Permeability (Array 2)
Cyrex Labs is the World’s leading immunological/intolerance laboratory in the world. The Array 2 was specifically designed to measure antibodies that appear when the integrity of the intestinal wall is compromised.
Leaky gut or intestinal permeability is a frequent occurring condition in the modern world. As the name implies, Leaky gut is a condition where the intestinal wall lets undigested food particles or other improper substances pass into the bloodstream.
There are a few known antigens present in with Intestinal permeability and those include Actomyosin, Occludin, Zonulin and Lipopolysaccharides (LPS). These test for different kinds of Leaky gut and will give a few hints about the possible causes.
LPS are large molecules found in gram-negative bacteria. They are endotoxins and trigger a strong immune response if absorbed. This reveals macromolecule-sized infiltration through intestinal barrier into systemic circulation.
Occludin is part of the main component of proteins holding together tight junctions (that connect individual intestinal wall cells to each other). The detection of Occludin antibodies suggest that tight junctions are breaking down. This shows the mechanism involved in damaging the intestinal barrier membrane.
Zonulin is the protein that directly regulates the permeability of the intestine. Antibodies to zonulin indicate compromised tight junction regulation. This can be a clue to presence of an ongoing mechanism involved in damaging the intestinal barrier.
Actomyosin forms a protein complex that regulates intestinal barrier function by maintaining tight functions. This measures the mechanism involved in damaging the intestinal barrier.
Cyrex labs measures 7 different antigens that are indicative of leaky gut.
The best test for leaky gut
Why is Cyrex Labs Array 2 the best test for Leaky gut?
The other option most widely used today is the Lactulose/Mannitol test and it’s been a helpful tool in the past 40 years. In this test you drink a solution of Lactulose and Mannitol and them measure its levels in urine or blood.
Lactulose absorption suggest a “tear” in the gut barrier and thus intestinal permeability and here’s the first misconceptions as this indicates minute leak rather than a tear. Lactulose has a low molecular weight and does not reflect food protein and immune response. The second problem with this test is that it measures only the transfer or small molecules through paracellular but not transcellular pathway.
Cyrex Array 2 therefore measures food like size molecules that trigger immune responses and includes both, paracellular and transcellular pathways.
Cyrex’s Four Pillars of Excellence:
Antigen Purification System™ – ensures assessment to the un-adulterated antigen, resulting in greater specificity.
Optimized Antigen Concentration™ – optimum protein ratios to detect immune reactivity (i.e. Beef is much higher in protein than Oranges).
Antigen Specific Validation™ – single antigen validation, rather than one arbitrarily chosen reference curve entire group of antigens.
Parallel Testing Technology™ – each specimen is validated in side-by-side duplicate.
Together, the Four Pillars of Excellence ensure accurate results.
Completing the test
Completing the test is easy. Everything you need is included in the collection kit and you will also get detailed instructions as a downloadable PDF file once your order is complete.
This is a blood test so you will have to schedule a blood draw at your local laboratory. Any local laboratory should be able to complete the blood draw and process the samples. Please call your local lab and ask them if they can take your blood and process it in a centrifuge and separate the serum in the provided standard vials.
It’s really a simple and standard procedure but please make sure you can do it before you order this test.
About Cyrex laboratories
Cyrex Labs is an advanced clinical laboratory focusing on mucosal, cellular, and humoral immunology and specializing in antibody arrays for complex thyroid, gluten, and other food-associated autoimmunities and related neurodysregulation. Cyrex’s Scientific Advisory Board, comprised of experts from a variety of medical and research disciplines, brings together the latest findings from medical research and the assessment needs of today’s healthcare professionals. Out of this collaboration, Cyrex develops the next generation of clinical lab testing that is required to care for present-day complex maladies.