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Cyrex Labs Leaky gut test (Array 2)
€275.00
The best Leaky gut/intestinal permeability test.
In stock (can be backordered)
- Description
- Additional information
- What is Leaky Gut exactly?
- Who should take this test?
- Type, Markers & Sample results
- Reviews (0)
Cyrex Labs Leaky Gut test/Intestinal Permeability (Array 2)
Cyrex Labs is the World’s leading immunological/intolerance laboratory in the world. The Array 2 was specifically designed to measure antibodies that appear when the integrity of the intestinal wall is compromised.
Leaky gut or intestinal permeability is a frequent occurring condition in the modern world. As the name implies, Leaky gut is a condition where the intestinal wall lets undigested food particles or other improper substances pass into the bloodstream.
There are a few known antigens present in with Intestinal permeability and those include Actomyosin, Occludin, Zonulin and Lipopolysaccharides (LPS). These test for different kinds of Leaky gut and will give a few hints about the possible causes.
LPS are large molecules found in gram-negative bacteria. They are endotoxins and trigger a strong immune response if absorbed. This reveals macromolecule-sized infiltration through intestinal barrier into systemic circulation.
Occludin is part of the main component of proteins holding together tight junctions (that connect individual intestinal wall cells to each other). The detection of Occludin antibodies suggest that tight junctions are breaking down. This shows the mechanism involved in damaging the intestinal barrier membrane.
Zonulin is the protein that directly regulates the permeability of the intestine. Antibodies to zonulin indicate compromised tight junction regulation. This can be a clue to presence of an ongoing mechanism involved in damaging the intestinal barrier.
Actomyosin forms a protein complex that regulates intestinal barrier function by maintaining tight functions. This measures the mechanism involved in damaging the intestinal barrier.
Cyrex labs measures 7 different antigens that are indicative of leaky gut.
The best test for leaky gut
Why is Cyrex Labs Array 2 the best test for Leaky gut?
The other option most widely used today is the Lactulose/Mannitol test and it’s been a helpful tool in the past 40 years. In this test you drink a solution of Lactulose and Mannitol and them measure its levels in urine or blood.
Lactulose absorption suggest a “tear” in the gut barrier and thus intestinal permeability and here’s the first misconceptions as this indicates minute leak rather than a tear. Lactulose has a low molecular weight and does not reflect food protein and immune response. The second problem with this test is that it measures only the transfer or small molecules through paracellular but not transcellular pathway.
Cyrex Array 2 therefore measures food like size molecules that trigger immune responses and includes both, paracellular and transcellular pathways.
Cyrex’s Four Pillars of Excellence:
Antigen Purification System™ – ensures assessment to the un-adulterated antigen, resulting in greater specificity.
Optimized Antigen Concentration™ – optimum protein ratios to detect immune reactivity (i.e. Beef is much higher in protein than Oranges).
Antigen Specific Validation™ – single antigen validation, rather than one arbitrarily chosen reference curve entire group of antigens.
Parallel Testing Technology™ – each specimen is validated in side-by-side duplicate.
Together, the Four Pillars of Excellence ensure accurate results.
Completing the test
Completing the test is easy. Everything you need is included in the collection kit and you will also get detailed instructions as a downloadable PDF file once your order is complete.
This is a blood test so you will have to schedule a blood draw at your local laboratory. Any local laboratory should be able to complete the blood draw and process the samples. Please call your local lab and ask them if they can take your blood and process it in a centrifuge and separate the serum in the provided standard vials.
It’s really a simple and standard procedure but please make sure you can do it before you order this test.
About Cyrex laboratories
Cyrex Labs is an advanced clinical laboratory focusing on mucosal, cellular, and humoral immunology and specializing in antibody arrays for complex thyroid, gluten, and other food-associated autoimmunities and related neurodysregulation. Cyrex’s Scientific Advisory Board, comprised of experts from a variety of medical and research disciplines, brings together the latest findings from medical research and the assessment needs of today’s healthcare professionals. Out of this collaboration, Cyrex develops the next generation of clinical lab testing that is required to care for present-day complex maladies.
| Weight | 315 g |
|---|---|
| Markers | Actomyosin IgA, Lipopolysaccharides (LPS) IgA, Lipopolysaccharides (LPS) IgG, Lipopolysaccharides (LPS) IgM, Occludin/Zonulin IgA, Occludin/Zonulin IgG, Occludin/Zonulin IgM |
| Test type | Blood test |
| Symptoms & health issues | Allergies, Asthma, Autoimmune diseases, Crohn's disease, Food Allergies, Gluten Sensitivity, IBD, Inflammation, Inflammatory bowel disease, Low energy, Low immune system, Multiple sclerosis, Neurological conditions, Psoriasis, Schizophrenia, Spondylitis, Type 1 Diabetes, Ulcerative colitis, Anxiety, depression or/and panic disorder, Rheumatoid arthritis |
What is Leaky Gut exactly?
In essence Leaky gut is the passage of undigested food proteins or other unattended molecules through the intestinal barrier into the bloodstream. Such molecules are then regarded as pathogenic and an immune response is mounted against them even if they are harmless.
Research confirms that the root cause for many of undesired immune reactions originates in the gastrointestinal tract. GI tract abnormality can compromise the integrity of the gut barrier and increases the entry of undigested antigens into the sub-mucosa and the circulation, thus challenging the immune system. Reaction to these antigens activates immune and inflammatory cascades, resulting in the production of pro-inflammatory cytokines and an array of antibodies, which further contributes to increased intestinal barrier permeability (or “ leaky gut” syndrome).
The exaggerated entrance of antigenic macromolecules across the gut epithelium can initiate production of, and perpetuate an ongoing increase in, multiple inflammatory cytokines and systemic chronic inflammation. This appears to be a required component for the trio of factors that lead to eventual autoimmune disease (genetic vulnerability, environmental exposure, and intestinal permeability).
The single-cell epithelial lining in the intestines forms an amazingly large surface area (300-m2, about the size of a tennis court), which represents the single largest interface between our bodies and the external environment. The function of intestinal mucosa is far more than just transportation of nutrients; it balances the needs for a barrier against a hostile environment, like the skin, with the necessity of active and passive transport, like the renal tubule. The intestinal mucosal cells favor fluxes of nutrients, regulate ion and water movements, and limit host contact with the massive intraluminal load of dietary antigens and microbes. An intact intestinal barrier is, therefore, critical to normal physiological function and the prevention of disease.
Intestinal permeability pathways
Depending on the damage either to the intestinal epithelial cells, unwanted molecules can pass directly through the sell or in between them (if the tight junctions are compromised).
Cyrex Array 2 measures both intestinal permeability pathways.
Who should take this test?
This test is suitable for everybody that suspect they may have Leaky gut.
It’s best suited for patients who:
- Present with multiple symptom complaints (including Chronic Fatigue Syndrome).
- Suffer from abnormal immune cell count and function (including autoimmune diseases).
- Have multiple food sensitivity.
It is hard to pinpoint exact symptoms as leaky gut manifests in different diseases. Intestinal permeability is connected to:
- Gluten Sensitivity and Celiac disease
- Food Allergies
- Inflammatory bowel disease (Ulcerative Colitis and Crohn’s disease)
- Numerous autoimmune diseases (Rheumatoid Arthritis, Psoriasis, Type 1 Diabetes, Spondylitis, etc.)
- Neurological conditions (Multiple Sclerosis, Guillain Barré Syndrome, etc.)
- Cognitive Dysfunction (depression, anxiety, Schizophrenia, etc.)
- Others
People that are more likely to have Leaky gut have:
- A family history of connected diseases
- Dysbiosis43 and microorganism invasions of (bacteria, yeast, viruses, parasites)
- Traumas including surgical and non-surgical lesions
- Stress due to disease, starvation, sustained strenuous exercise, radiation
- Other environmental factors such as medications, allergenic foods
- Current or past use of antibiotics, steroids, NSAIDs
- History of chemotherapy or radiation treatment
- History of chronic yeast infection
- Digestive enzyme insufficiencies
- Diet history of:
- Standard American Diet
- low fiber diets
- excessive alcohol or caffeine consumption
- unknown exposure to food allergens used as fillers in cosmetics, medications, nutrients
Type, Markers & Sample results
What kind of test is this?
This is a Blood test.
What markers are being tested?
This test measures antigens connected to intestinal permeability. The reported markers are:
- Actomyosin IgA
- Occludin/Zonulin IgG
- Occludin/Zonulin IgA
- Occludin/Zonulin IgM
- Lipopolysaccharides (LPS) IgG
- Lipopolysaccharides (LPS) IgA
- Lipopolysaccharides (LPS) IgM
Sample results
Download sample results in PDF
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